COVID-19 and Your Microbiome

By Sabine Hazan, MD

|March 19, 2020

“In a war against bugs the medical doctors are the soldiers”. Dr. Sabine Hazan

Novel coronavirus, officially known as COVID-19, has now been declared a global pandemic.  Originating in bats in the city of Wuhan, China, the virus attacks the lungs, causing fevers, coughing, and shortness of breath.  However, as the virus has also been found to lodge in the small intestine, other symptoms including nausea, vomiting, and diarrhea have also been reported, as well as headaches, fatigue, and chills.  These symptoms can worsen to the degree that oxygen support and even ventilation are required.  Diagnostic testing is done via a technique called real time PCR, also known as qPCR.  This test is very sensitive, meaning that it picks up on positive results.  It’s also very specific, meaning that it doesn’t find other viruses and indicate positive for COVID-19.  There is currently no FDA approved treatment or cure, although there are numerous clinical trials being conducted to test whether existing medications might be effective in treating the virus.  In one study, in a little less than half of patients with COVID-19, there was a decrease of T cells (T lymphocytes).  T cells play many important roles in the immune response, and as such are essential to human health.

 

Young, healthy people are at a lower risk for developing serious illness.  Those at elevated risk include the elderly, and people with chronic illness.  Of particular concern are older adults with heart disease, lung disease, or diabetes.  Other high-risk populations include patients taking immunosuppressive medications like prednisone, patients with autoimmune diseases, cancer patients on chemotherapy, patients with HIV or hepatitis, patients with liver or kidney disease, and patients with lung disease such as asthma or COPD.

 

Scientists worldwide have been working around the clock to understand the virus, and how to combat it.  Part of that study includes discovering the structure of the virus.  This allows scientists to see potential targets for treatment.  One such target is the ACE2 receptor binding domain (RBD), which is what allows the virus to adhere to its objective, in this case, human lungs.  This domain is found on the spikes that give the coronavirus it’s name.  The binding between COVID-19 and ACE2 is a potential place to direct treatments.  The authors of the above study suggested that antibodies and small molecules should be developed to do precisely that.

 

While ACE2 is present in the lungs, allowing people to get pneumonia, it is also present in the intestines, kidneys, and testis.  The significance of this is that the virus could be shed in stool, and thus be transmitted via the fecal oral route.  It also suggests that the gut microbiome of patients with COVID-19 could be detrimentally impacted by the virus.  Although only a small percentage of patients have GI symptoms, the prevalence of ACE2 in the GI tract suggest that this could be a reservoir of the virus, which would have a dramatic impact on the population of microbes already present there.

 

Future studies should include sequencing of the microbiome of patients following successful treatment for COVID-19, to determine the nature of imbalance, or dysbiosis, caused by the virus.  Only then can appropriate treatment measures for this imbalance be established.

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    Sistemdeki çalışma sürecimiz her gün sanatçıları takip edip siz değerli okurlarımız için en güncel ilahi sanatçılarına ait en güncel ilahilerin sözlerini ve dinleyebileceğiniz bir
    bağlantıyı sitemize her gün eklemekteyiz. Sitemiz üzerinden o
    günün en çok okunan ilahi sözlerine erişebilir eriştiğiniz ilahi sözünü değerli arkadaşlarınız ile paylaşabilirsiniz.

    Bunların yanı sıra güncellenen ilahi arşivimiz ile sizlere 7/24 websitemiz üzerinden ilahi sözleri
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    ilahi sözleri

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    | reconhecer | compreender | reconhecer | saber} {para que | para que} eu
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    {É | É} {apropriado | perfeito | o melhor} momento para fazer {alguns | alguns} planos para {o futuro | longo prazo
    | o longo prazo} e {é | é} hora de ser
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    | desejo} {sugerir | recomendar | aconselhar} você {alguns | alguns}
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    | aprender} {mais | ainda mais} {coisas | questões} {aproximadamente | sobre} isso!
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    {Estive | Estive} {surfando | navegando} {online | on-line}
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    design | design e estilo | design}. |
    {Eu amo | Eu realmente gosto | Eu gosto | Eu gosto | Todo mundo adora} o que vocês {são | geralmente
    | tendem a ser} também. {Este tipo de | Este tipo de | Tal
    | Este tipo de} trabalho inteligente e {exposição | cobertura | relatório}!
    Continuem com os trabalhos {excelente | ótimo | muito bom | ótimo
    | bom | incrível | fantástico | excelente | incrível | maravilhoso}
    que eu {incorporado | adicionei | incluí} vocês ao {| meu |
    nosso | meu pessoal | meu próprio} blogroll.
    {Olá | Olá | Olá | Olá | Olá | Olá}, você se
    importaria de {declarar | compartilhar} com qual plataforma de blog você está {trabalhando | usando}?
    Estou {procurando | planejando | vou} começar meu próprio
    blog {em um futuro próximo | em breve}, mas estou tendo um momento
    {difícil | difícil | difícil} de {tomar uma decisão | selecionar | escolher | decidir} entre o BlogEngine / WordPress / B2evolution e Drupal.
    A razão de eu perguntar é porque seu {design e estilo | design | layout} parece
    diferente da maioria dos blogs e eu estou procurando por algo {completamente único | único}.
    PS {Minhas desculpas | Desculpas | Desculpe} por {ficar | fora do tópico, mas eu tinha
    que perguntar! |
    {Olá | Olá | Olá | Olá | Olá | Olá},
    você se importaria de me informar com qual {webhost | empresa de hospedagem | host} você está {utilizando | trabalhando com | usando}?
    Carreguei seu blog em 3 {completamente diferentes | diferentes} {navegadores
    de internet | navegadores da web | navegadores} e devo dizer que este blog carrega muito {mais rápido | mais rápido} do que a maioria.

    Você pode {sugerir | recomendar} um bom provedor de {hospedagem
    na Internet | hospedagem na web | hospedagem} a um preço {honesto
    | razoável | justo}? {Muito obrigado | Kudos | Saúde |
    Obrigado | Muito obrigado | Obrigado}, agradeço!

    |
    {Eu amo | Eu realmente gosto | Eu gosto | Todo mundo adora} {quando as pessoas | quando as pessoas | quando as pessoas |
    sempre que as pessoas} {vêm juntos | se reúnem} e compartilham {opiniões | pensamentos | pontos de vista |
    ideias}. Ótimo {blog | site | site}, {continue assim | continue
    o bom trabalho | continue com ele}! |
    Obrigado pela {auspiciosa | boa} redação. É, de facto, foi uma diversão
    que representam. Olhe avançado para {far | mais} adicionado agradável de você!

    {A propósito | No entanto}, como {podemos | poderíamos} nos comunicar?

    |
    {Olá | Olá | Olá | Olá | Olá} só queria avisar
    rapidamente. As {text | words} em seu {content | post | article}
    parecem estar saindo da tela no {Ie | Internet explorer | Chrome | Firefox | Safari | Opera}.
    Não tenho certeza se este é um problema de {formatação | formatação} ou algo a ver com a compatibilidade do {navegador | navegador da Internet | navegador}, mas eu {pensado | figurado}
    postaria para informá-lo. O {estilo e design | design e estilo | layout | design}
    parece ót